GAIT: Gene expression Analysis for Interval Time

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GAIT: Gene expression Analysis for Interval Time.

Motivation Despite the potential usefulness, the association analysis of gene expression with interval times of two events has been hampered because the occurrence of events can be censored and the conventional survival analysis is not suitable to handle two censored events. However, the recent advances of multivariate survival analysis considering multiple censored events together provide an u...

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Gene set analysis methods, which consider predefined groups of genes in the analysis of genomic data, have been successfully applied for analyzing gene expression data in cross-sectional studies. The time-course gene set analysis (TcGSA) introduced here is an extension of gene set analysis to longitudinal data. The proposed method relies on random effects modeling with maximum likelihood estima...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2018

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/bty111